Publications
2023
Palomba M., Vecchio D., Allavena G., Capaccio V., De Mei C., Scarpelli R., Grimaldi B.
Identification of a Dual Autophagy and REV-ERB Inhibitor with in Vivo Anticancer Efficacy
Journal of Medicinal Chemistry
2022
Greco R., Demartini C., Zanaboni A.M., Francavilla M., Reggiani A., Realini N., Scarpelli R., Piomelli D., Tassorelli C.
Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine
Journal of Headache and Pain, vol. 23, (no. 1)
2020
Caputo S., Di Martino S., Cilibrasi V., Tardia P., Mazzonna M., Russo D., Penna I., Summa M., Bertozzi S.M., Realini N., Margaroli N., Migliore M., Ottonello G., Liu M., Lansbury P., Armirotti A., Bertorelli R., Ray S.S., Skerlj R., Scarpelli R.
Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors
Journal of Medicinal Chemistry, vol. 63, (no. 24), pp. 15821-15851
2020
Di Martino S., Tardia P., Cilibrasi V., Caputo S., Mazzonna M., Russo D., Penna I., Realini N., Margaroli N., Migliore M., Pizzirani D., Ottonello G., Bertozzi S.M., Armirotti A., Nguyen D., Sun Y., Bongarzone E.R., Lansbury P., Liu M., Skerlj R., Scarpelli R.
Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors
Journal of Medicinal Chemistry, vol. 63, (no. 7), pp. 3634-3664
2016
Scarpelli R., Sasso O., Piomelli D.
A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation
ChemMedChem, pp. 1242-1251
2016
Veronesi M., Giacomina F., Romeo E., Castellani B., Ottonello G., Lambruschini C., Garau G., Scarpelli R., Bandiera T., Piomelli D., Dalvit C.
Fluorine nuclear magnetic resonance-based assay in living mammalian cells
Analytical Biochemistry, vol. 495, pp. 52-59
2016
Falchi F., Bertozzi S.M., Ottonello G., Ruda G.F., Colombano G., Fiorelli C., Martucci C., Bertorelli R., Scarpelli R., Cavalli A., Bandiera T., Armirotti A.
Kernel-Based, Partial Least Squares Quantitative Structure-Retention Relationship Model for UPLC Retention Time Prediction: A Useful Tool for Metabolite Identification
Analytical Chemistry, vol. 88, (no. 19), pp. 9510-9517
2016
Migliore M., Habrant D., Sasso O., Albani C., Bertozzi S.M., Armirotti A., Piomelli D., Scarpelli R.
Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies
European Journal of Medicinal Chemistry, vol. 109, pp. 216-237
2016
Migliore M., Pontis S., Fuentes de Arriba A.L., Realini N., Torrente E., Armirotti A., Romeo E., Di Martino S., Russo D., Pizzirani D., Summa M., Lanfranco M., Ottonello G., Busquet P., Jung K.-M., Garcia-Guzman M., Heim R., Scarpelli R., Piomelli D.
Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis
Angewandte Chemie - International Edition, vol. 55, (no. 37), pp. 11193-11197
2015
Prati F., De Simone A., Armirotti A., Summa M., Pizzirani D., Scarpelli R., Bertozzi S.M., Perez D.I., Andrisano V., Perez-Castillo A., Monti B., Massenzio F., Polito L., Racchi M., Sabatino P., Bottegoni G., Martinez A., Cavalli A., Bolognesi M.L.
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease
ACS Chemical Neuroscience, vol. 6, (no. 10), pp. 1665-1682
2015
Bach A., Pizzirani D., Realini N., Vozella V., Russo D., Penna I., Melzig L., Scarpelli R., Piomelli D.
Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies
Journal of Medicinal Chemistry, vol. 58, (no. 23), pp. 9258-9272
2015
De Mei C., Ercolani L., Parodi C., Veronesi M., Vecchio C.L., Bottegoni G., Torrente E., Scarpelli R., Marotta R., Ruffili R., Mattioli M., Reggiani A., Wade M., Grimaldi B.
Dual inhibition of REV-ERBβ and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells
Oncogene, vol. 34, (no. 20), pp. 2597-2608
2015
Prati F., De Simone A., Bisignano P., Armirotti A., Summa M., Pizzirani D., Scarpelli R., Perez D.I., Andrisano V., Perez-Castillo A., Monti B., Massenzio F., Polito L., Racchi M., Favia A.D., Bottegoni G., Martinez A., Bolognesi M.L., Cavalli A.
Multitarget drug discovery for Alzheimer's disease: Triazinones as BACE-1 and GSK-3β inhibitors
Angewandte Chemie - International Edition, vol. 54, (no. 5), pp. 1578-1582
2015
Sasso O., Migliore M., Habrant D., Armirotti A., Albani C., Summa M., Moreno-Sanz G., Scarpelli R., Piomelli D.
Multitarget Fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage
FASEB Journal, vol. 29, (no. 6), pp. 2616-2627
2015
Colombano G., Albani C., Ottonello G., Ribeiro A., Scarpelli R., Tarozzo G., Daglian J., Jung K.-M., Piomelli D., Bandiera T.
O-(triazolyl)methyl carbamates as a novel and potent class of Fatty Acid Amide Hydrolase (FAAH) inhibitors
ChemMedChem, vol. 10, (no. 2), pp. 380-395