Publications
						
					2025
								Torielli L., Castelli M., Milani F., Heritz J.A., Cayaban S.J., Hernandez J., Serapian S.A., Magni A., Frasnetti E., Doria F., Pirota V., Wengert L.A., Woodford M.R., Lodigiani G., Bergamaschi G., Veronesi M., Bandiera T., Girotto S., Paladino A., Prodromou C., Backe S.J., Bourboulia D., Canciani A., Arrigoni C., Lolicato M., Gestwicki J.E., Mollapour M., Colombo G.
								Design of multi-target peptide modulators for protein chaperone networks
								Structure
								
							2025
								Bresciani V., Rinaldi F., Franco P., Girotto S., Cavalli A., Langer J. D., Masetti M., Bernetti M.
								Dissecting the RAD51-BRC4 Interaction Landscape through Integrative Molecular Simulations and Experimental Biophysics
								Journal of Chemical Information and Modeling
								
							
								
								
								    
										Article
									
								
								
									Journal
								
								
							
						2025
								Masi M., Poppi L., Previtali V., Nelson S.R., Wynne K., Varignani G., Falchi F., Veronesi M., Albanesi E., Tedesco D., De Franco F., Ciamarone A., Myers S.H., Ortega J.A., Bagnolini G., Ferrandi G., Farabegoli F., Tirelli N., Di Stefano G., Oliviero G., Walsh N., Roberti M., Girotto S., Cavalli A.
								Investigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity
								Cell Death Discovery, vol. 11, (no. 1)
								
							2025
								Codino A., Spagnoletti L., Olobardi C., Cuomo A., Santos-Rosa H., Palomba M., Margaroli N., Girotto S., Scarpelli R., Luan S.-L., Crocco E., Bianchini P., Bannister A.J., Gustincich S., Kouzarides T., Rizzo R., Barbieri I., Cremisi F., Vignali R., Pandolfini L.
								METTL9 sustains vertebrate neural development primarily via non-catalytic functions
								Nature Communications, vol. 16, (no. 1)
								
							2025
								Di Martino R.M.C., Russo D., Penna I., Demuro S., Dalle Vedove A., Spagnuolo R., Ottonello G., Bertozzi S.M., Summa M., Desantis J., Valeri A., Pruccoli L., Tripathi S.K., Tarozzi A., Storici P., Girotto S., Bertorelli R., Armirotti A., Cruciani G., Bandiera T., Cavalli A., Bottegoni G.
								Rational optimization of D3R/GSK-3β dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies
								European Journal of Medicinal Chemistry, vol. 297
								
							2025
								Rinaldi F., Girotto S.
								Understanding how structure shapes the architecture of homologous recombination
								Current Opinion in Structural Biology
								
							
								
								
								    
										Review
									
								
								
									Journal
								
								
							
						2024
								Balboni B., Marotta R., Rinaldi F., Milordini G., Varignani G., Girotto S., Cavalli A.
								An integrative structural study of the human full-length RAD52 at 2.2 Å resolution
								Communications Biology, vol. 7, (no. 1)
								
							2024
								Brindani N., Vuong L.M., La Serra M.A., Salvador N., Menichetti A., Acquistapace I.M., Ortega J.A., Veronesi M., Bertozzi S.M., Summa M., Girotto S., Bertorelli R., Armirotti A., Ganesan A.K., De Vivo M.
								Discovery of CDC42 Inhibitors with a Favorable Pharmacokinetic Profile and Anticancer In Vivo Efficacy
								Journal of Medicinal Chemistry, vol. 67, (no. 12), pp. 10401-10424
								
							2024
								Balboni B., Marotta R., Rinaldi F., Milordini G., Varignani G., Girotto S., Cavalli A.
								Human full-length RAD52 at 2.2 Å resolution: an integrative structural biology study
								Communications Biology
								
							
								
								
								    
										Article
									
								
								
									Journal
								
								
							
						2024
								Rinaldi F., Girotto S.
								Structure-based approaches in synthetic lethality strategies
								Current Opinion in Structural Biology, vol. 88
								
							2023
								Myers S. H., Poppi L., Rinaldi F., Veronesi M., Ciamarone A., Previtali V., Bagnolini G., Schipani F., Ortega Martínez J. A., Girotto S., Di Stefano G., Farabegoli F., Walsh N., De Franco F., Roberti M., Cavalli A.
								An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer
								European Journal of Medicinal Chemistry
								
							2023
								Brindani N., Vuong L.M., Acquistapace I.M., La Serra M.A., Ortega J.A., Veronesi M., Bertozzi S.M., Summa M., Girotto S., Bertorelli R., Armirotti A., Ganesan A.K., De Vivo M.
								Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer
								Journal of Medicinal Chemistry, vol. 66, (no. 8), pp. 5981-6001
								
							2023
								Balboni B., Masi M., Rocchia W., Girotto S., Cavalli A.
								GSK-3β Allosteric Inhibition: A Dead End or a New Pharmacological Frontier?
								International Journal of Molecular Sciences, vol. 24, (no. 8)
								
							2023
								Brusa I., Sondo E., Pesce E., Tomati V., Gioia D., Falchi F., Balboni B., Ortega Martinez J.A., Veronesi M., Romeo E., Margaroli N., Recanatini M., Girotto S., Pedemonte N., Roberti M., Cavalli A.
								Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5
								Journal of Medicinal Chemistry, vol. 66, (no. 14), pp. 9797-9822
								
							2023
								Rinaldi F., Schipani F., Balboni B., Catalano F., Marotta R., Myers S.H., Previtali V., Veronesi M., Scietti L., Cecatiello V., Pasqualato S., Ortega J.A., Girotto S., Cavalli A.
								Isolation and Characterization of Monomeric Human RAD51: A Novel Tool for Investigating Homologous Recombination in Cancer
								Angewandte Chemie - International Edition, vol. 62, (no. 51)