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Laura Cancedda

Senior Researcher Tenured - Principal Investigator
Brain Development and Disease
Laura Cancedda
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About

Laura Cancedda graduated in Medicinal Chemistry at the University of Genoa in 1999, with a thesis on the role of neurotrophic factors on neurotransmitter release. She received her Ph.D. in neurophysiology from Scuola Normale Superiore (Pisa, Italy) in 2003, under the supervision of Dr. Lamberto Maffei. In Pisa, she investigated the molecular and environmental basis of experience-dependent plasticity in the rat brain. In 2003, she moved to University of California at Berkeley in Dr. Poo’s laboratory where she focused her studies on molecular mechanisms of GABAergic-transmission modulation.

Currently, she holds a principal investigator position at the Italian Institute of Technology (IIT) in Genoa. Laura is a EMBO member, an alumna of the FENS KAVLI network of excellence and a former Dulbecco Telethon Institute researcher. Her laboratory investigates mechanisms of brain development in health and disease, with a strong translational focus on neurodevelopmental disorders.

Laura comes from a neurophysiological and neuropharmacological background. The techniques applied in her laboratory include, among others, in vitro electrophysiology on brain slices and cell cultures, in vivo transfection of nucleic acids (in utero electroporation), in vitro and in vivo pharmacology, immunohistochemistry, confocal imaging and multiomics, rodent behavioral testing.

Honors and Awards

2026-2030 Member of the EMBO Global Investigator Network selection committee.

2026    Winner of the INNLIFES prize – Protagonists of innovation in neurology.

2025    Elected European Molecular Biology Organization (EMBO) member

             Awarded the FIS 2 Advanced grant (modelled on the ERC advanced grant, 2M Euros).

             Program Committee officer member for the Federation of European Neuroscience Societies (FENS 2026).

            Female entrepreneurship award “Best scale up award”to IAMA therapeutics “La carica delle 101”, Milan, Italy.

2024-2027       Selected as a member of the Scientific Advisory Board (SAB) for the Scientific and Research and Innovation Agenda (SRIA) of the                                           Coordination and Support Action (CSA) BrainHealth for the planned European Partnership for Brain Health (EBPH), a new funding line of                            the European commission.

                          Alessandro Moretta prize, Research Ambassadors, Genoa Italy

                          Innovation prize by the Foreign Press Association (to Iama Therapeutics)

2023    Seal of Excellence certificate for ERC PoC 2023 DL2

2022    Finalist as Funder of IAMA therapeutics of the Finalist for Falling Walls Venture 2022.

2022    Founder and scientific advisor for IAMA therapeutics.

Scientific responsible and member of the steering committee for Clinical trial EudraCT 2015-005780-16 at the Bambino Gesù Hospital based on my research.

2019    Program Committee officer member for the Federation of European Neuroscience Societies (FENS)  (proposed by Italian Society for Neuroscience).

Proposed for the IBRO-Kemali Prize 2019

2018    National habilitation as full professor of Pharmacology

National habilitation as full professor of Physiology

2017- Scientific advisory board member of the Fondazione Pisana per la Scienza

2017    Selected among the best 100 young Italian scientists operating in Italy or abroad (Cartaditalia magazine)

2016    Awarded the European Research Council (ERC) consolidator grant.

The project was featured in the press release (7 projects featured out of 314 funded) for announcing the results of 2016 ERC CoG by the communication unit of the ERC.

Appointed scholar of the FENS-KAVLI network of excellence. https://fenskavlinetwork.org/ 

Young researcher award, memorial Mario Mai.

2015    Appointed assistant scientist at the Dulbecco Telethon Institute, Italy

2014    National habilitation as assistant professor of Physiology.

TRADECOM society adopted Telethon Project on Rett syndrome for communication to the lay public.

2013    Mention of honor, poster award, Convention Telethon, Italy.

Finalist at the scientific picture award “Beyond science”, Genova, Italy.

2011    Best poster award, Molecular Mechanisms in Neuroscience meeting, Rome, Italy.

2009    Young investigator award, Italian Society of Physiology (SIF), Italy.

2008    Best speaker award, Italian Society for Neuroscience (SINS), Milan, Italy.

2003    Ph.D. earned with Honors, Scuola Normale Superiore, Pisa, Italy.

2001    Travel award for participation to summer course “Structure, Function and Development of the Visual System”, Cold Spring Harbor Laboratory (CSHL), U.S.A.

1999    Graduation with Honors and Distinction in Major, University of Genoa, Italy.

1997    Scholarship for extracurricular departmental activities, University of Genoa, Italy.

Education

Title: Ph.D. Neurophysiology, Neurodevelopment
Institute: Scuola Normale Superiore (Ecole Normale Superieure)
Location: Pisa
Country: Italy
From: 2000 To: 2003

Title: MSc Med. Chemistry, Neuropharmacology
Institute: Università degli Studi di Genova
Location: Genova
Country: Italy
From: 1994 To: 1999

Experience External

Title: Assistant scientist
Institute: Dulbecco Telethon Insitute
Location: null
Country: Italy
From: 2016 To: null

Title: Post doctoral fellow (Advisor: Poo MM)
Institute: University of California
Location: Berkeley
Country: USA
From: 2003 To: 2007

Title: Graduate student (Advisor: Maffei L)
Institute: Scuola Normale Superiore
Location: Pisa
Country: Italy
From: 2000 To: 2003

Top Publications
2026
Morelli G., Visintin G., Gelli E., Serani A., Bartolucci M., Uccella S., D'Apruzzo M., Preiti D., Chellali M.M., Cucinelli A., Rastogi M., Falappa M., Scalabrini A., Turecki G., Petretto A., Tucci V., Cancedda L.
Traumatic life experiences during critical periods lead to diverse developmental trajectories
Cell Reports Medicine, vol. 7, (no. 6)
2024
Ruiz Munevar M.J., Rizzi V., Portioli C., Vidossich P., Cao E., Parrinello M., Cancedda L., De Vivo M.
Cation Chloride Cotransporter NKCC1 Operates through a Rocking-Bundle Mechanism
Journal of the American Chemical Society, vol. 146, (no. 1), pp. 552-566
Article Journal
2024
Potenzieri A., Uccella S., Preiti D., Pisoni M., Rosati S., Lavarello C., Bartolucci M., Debellis D., Catalano F., Petretto A., Nobili L., Fellin T., Tucci V., Ramenghi L.A., Savardi A., Cancedda L.
Early IGF-1 receptor inhibition in mice mimics preterm human brain disorders and reveals a therapeutic target
Science advances, vol. 10, (no. 9)
Article Journal
2024
Rastogi M., Bartolucci M., Nanni M., Aloisio M., Vozzi D., Petretto A., Contestabile A., Cancedda L.
Integrative multi-omic analysis reveals conserved cell-projection deficits in human Down syndrome brains
Neuron
Article Journal
2020
Savardi A., Borgogno M., Narducci R., La Sala G., Ortega J.A., Summa M., Armirotti A., Bertorelli R., Contestabile A., De Vivo M., Cancedda L.
Discovery of a Small Molecule Drug Candidate for Selective NKCC1 Inhibition in Brain Disorders
Chem, vol. 6, (no. 8), pp. 2073-2096
All Publications
2026
Gobbo F., Jacob A., Pinto B., Mainardi M., Cancedda L., Cattaneo A.
Distinct spatial distribution of potentiated dendritic spines in encoding- and recall-activated hippocampal neurons
Frontiers in Molecular Neuroscience, vol. 18
2026
Costanzo F., Mongiovi V.M., Alfieri P., Pontrelli G., Abbate S., De Palma L., Chinali M., Massella L., Scorpecci A., Rocchi F., Fuca E., Averna R., Rava L., Rossetti S., Franco L., Contestabile A., Cancedda L., Vicari S.
Efficacy of bumetanide for cognitive improvement in children and adolescents with Down syndrome: study protocol of a randomised, double-blind, placebo-controlled trial
BMJ Open, vol. 16, (no. 2)
Article Journal
2026
Rovere M., Beatini S., Giantomasi L., Tuntevski K., Contestabile A., De Pietri Tonelli D., Cancedda L.
Small Non-Coding RNA Dysregulation in the Microglia from a Mouse Model of Down Syndrome
FENS Forum 2026
Poster Conference
2026
Morelli G., Visintin G., Gelli E., Serani A., Bartolucci M., Uccella S., D'Apruzzo M., Preiti D., Chellali M.M., Cucinelli A., Rastogi M., Falappa M., Scalabrini A., Turecki G., Petretto A., Tucci V., Cancedda L.
Traumatic life experiences during critical periods lead to diverse developmental trajectories
Cell Reports Medicine, vol. 7, (no. 6)
2025
Rovere M., De Pietri TOnelli D., Contestabile A., Cancedda L.
A New Potential Molecular Mechanism Linking Trisomy to Cellular Outcomes in Down Syndrome
RNA Flagship Retreat IIT
Poster Conference
Awards and Achievements
2026
Cancedda L.
External referee PhD thesis committee member at Open University.
2026
Cancedda L.
External referee PhD thesis committee member at Scuola Normale Superiore
2026
Cancedda L.
Female entrepreneur award “La carica delle 101”, Milan, Italy.
2026
Cancedda L.
KOL for Academic Language Experts
2026
Cancedda L.
Member of the EMBO Global Investigator Network selection committee (2026-2030)
Organized Events
2026
Cancedda L.
Member of the programme committee of the European federation for Neuroscience (FENS) meeting 2026
2024
Cancedda L.
T21RS 2024 International Conference - Local Organizing Committee, Rome
2022
Cancedda L.
Organizer of the meeting cation-chloride co-transporters in neurodevelopmental diseases, Marseille, France. (14-19 September 2022)
2022
Cancedda L.
Organizing committee of the meeting T21 Research Society, meeting, Rome, Italy 2024
2021
Cancedda L.
Collaboration (with Dr. Vicari, Bambino Gesù Hospital, Rome) on a clinical trial for the use of modulators of Cl transporters to rescue cognitive impairment in individuals with Down syndrome.